There is no way to control the printer using Simplify 3D. There is no way to establish a connection between the printer and a PC using Simplify 3D.
The only connection which can be established is by mirroring the user interface with the IP address generated by the printer when connected to a network.
Print settings in the Creatr Software can be directly updated in under 'print'.
The latest Simplify 3D profiles can be downloaded using the following links:
Bolt - Simplify3D settings
Bolt Pro - Simplify3D settings
To use the profiles, choose File, then Import FFF Profile and be sure to select the correct profile in your process. You can also watch this video.
Request more information on the Bolt (Pro) firmware and how to update this via the Ticket System
Bolt Pro Firmware